Measurement of Morphologic Changes Induced by Trauma with the Use of Coherence Tomography in Porcine Vocal Cords |
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Authors: | Nader A. Nassif BS William B. Armstrong MD Johannes F. de Boer PhD Brian J.F. Wong MD FACS |
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Affiliation: | Department of Physics and Astronomy, University of California, Irvine, Orange, CA 92868-3201, USA. |
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Abstract: | BACKGROUND AND OBJECTIVE: To evaluate the ability of optical coherence tomography (OCT) (a noncontact, high-resolution imaging technique that generates detailed cross-sectional images of tissue structure) to image and document acute response to trauma in the larynx. MATERIALS AND METHODS: Porcine larynges were dissected to expose the vocal cords. Vocal cords were imaged with 1310 nanometer (nm) light source with a bandwidth of 75 nm at 1 frame/second (s). Vocal cord injuries were simulated by applying topical phenolic acid, injecting titanium dioxide into the submucosa, and carbon dioxide laser irradiation. RESULTS: The epithelium, basement membrane, and lamina propria were clearly delineated, and the effect of each intervention could be monitored as lesions progressed. The OCT image corresponded closely with histology. CONCLUSION: OCT is a powerful imaging tool with the potential for use in real time and has potential for multiple clinical applications in the larynx. |
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