慢性牙周炎和冠心病患者血清CRP、sICAM-1水平的研究

目的：测定慢性牙周炎（chronic periodontitis,CP）和冠心病（coronary atherosclerotic heart disease,CHD）患者血清C反应蛋白（c-reactive protein,CRP）、可溶性细胞间黏附分子1（soluble intercellular adhesion molecule-1,sICAM-1）的水平,探讨CP和CHD的相关性以及CRP、sICAM-1在二者相关性中的可能作用。方法：选择无系统性疾病的中重度CP患者29例,27例经冠状动脉造影确诊CHD病但无牙周炎患者;健康对照组30例,收集各组血清,分别用免疫比浊法和ELISA法测定CRP、sICAM-1水平。结果：实验组（CP和CHD组）与对照组之间的血清CRP、sICAM-1水平存在显著性差异（P﹤0.01）,CP组与CHD组之间差异无统计学意义（P〉0.05）。结论：CP和CHD患者血CRP、sICAM-1的水平升高,CP影响血CRP、sICAM-1的浓度,CRP、sICAM-1可能与牙周炎和冠心病病理机制密切相关,可能是CP和CHD关联的中介之一。

The levels of serum CRP and sICAM-1 in patients with chronic periodontitis and coronary atherosclerotic heart disease

Objective： To compare the levels of serum C-reactive protein （CRP） and soluble intercellular adhesion molecule-1 （sICAM -1） in patients with chronic periodontitis and coronary atherosclerotic heart disease,probe into the relation of periodontal disease and coronary atherosclerotic heart disease （CHD）and the effect of CRP and sICAM-1. Method： Twenty-seven CHD patients referred for diagnostic coronary angiography were assessed for no periodontitis by no periodontal attachment loss.Twenty-nine chronic periodontitis patients were assessed for no system diseases. Thirty healthy cases passed the periodontal examination by the same dentist were taken as control group.All the cases were tested on the serum concentration of CRP,sICAM-1 by immune turbidimetry and sensitive enzyme-linked immunosorbent assay respectively. Result： The level of serum CRP and sICAM-1 in experiments group （CPand CHD） were significantly higher than control group （P 〈 0.01）. The levels of serum CRP and sICAM-1 in CP patients were higher than CHD patients （Pdy0.05）. Conclusion： CRP and sICAM-1 were significantly associated with the pathological mechanism of periodontitis and CHD, but the relationship of both diseases still need to be further confirmed.