康莱特联合多西紫杉醇和奥沙利铂治疗晚期NSCLC的临床研究 |
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引用本文: | 何安兵,王群,罗云秀,童文先,刘爱华.康莱特联合多西紫杉醇和奥沙利铂治疗晚期NSCLC的临床研究[J].实用肿瘤杂志,2012,27(6):653-655. |
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作者姓名: | 何安兵 王群 罗云秀 童文先 刘爱华 |
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作者单位: | 武汉市第五医院肿瘤科,湖北武汉,430050 |
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摘 要: | 目的 观察康莱特注射液联合多西紫杉醇和奥沙利铂治疗晚期非小细胞肺癌的疗效.方法 72例Ⅲ~Ⅳ期非小细胞肺癌患者随机分为联合治疗组40例和单纯化疗组32例.联合治疗组应用多西紫杉醇和奥沙利铂化疗同时加用康莱特注射液,单纯化疗组为多西紫杉醇联合奥沙利铂化疗.结果 联合治疗组近期有效率为50.0%,单纯化疗组为37.5%,两组差异无统计学意义(P =0.139).联合治疗组生存质量优于单纯化疗组(P=0.003);联合治疗组改善体质量方面亦优于单纯化疗组,差异有统计学意义(P =0.009).在化疗不良反应方面,联合治疗组Ⅱ度以上骨髓抑制和神经毒性发生率均低于单纯化疗组(P=0.047,P=0.027).结论 康莱特注射液在联合多西紫杉醇和奥沙利铂治疗晚期非小细胞肺癌中,有增效减毒的作用,值得临床应用.
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关 键 词: | 癌 非小细胞肺/中西医结合疗法 肺肿瘤/中西医结合疗法 薏苡仁△/治疗应用 紫杉烷类/治疗应用 有机铂化合物/治疗应用 抗肿瘤联合化疗方案/治疗应用 治疗结果 随机对照试验 |
Kanglaite injection combined with docetaxel and oxaliplatin in treatment of advanced NSCLC |
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Institution: | HE An-bing,WANG Qun,LUO Yun-xiu,et al(Department of Oncology,the Fifth Hospital of Wuhan City,Wuhan,430050,China) |
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Abstract: | Objective To investigate the efficacy and adverse reactions of Kanglaite(KLT) injection combined with docetaxel and oxaliplatin in treatment of advanced non-small cell lung cancer(NSCLC).Methods Seventy-two patients with stage Ⅲ ~ Ⅳ NSCLC were randomly divided into two groups:40 patients received KLT combined with docetaxel and oxaliplatin(combined treatment group) and 32 patients were treated with docetaxel and oxaliplatin alone(control group).Results The short-term response rate of combined treatment group was 50.0% and that of control group was 37.5%;there was no statistically significant difference between two groups(P=0.139).The quality of life in combined treatment group was better than that in control group(P=0.003).Similarly,combined treatment group was better than control group in improving body weight(P=0.009).The incidence of the garde Ⅱ or above bone marrow suppression and neurotoxicity in combined treatment group were significantly lower than those in control group(P=0.047,P=0.027).Conclusion KLT injection with docetaxel and oxaliplatin in treatment of advanced NSCLC can improve the efficacy and reduce the toxicity of chemotherapy,which is worth of clinical application. |
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Keywords: | carcinoma non-small-cell lung/ZHONG XI YI JIE HE LIAO FA lung neoplasms/ZHONG XI YI JIE HE LIAO FA SEMEN COICIS/therapeutic use taxoids/therapeutic use organoplatinum compounds/therapeutic use antineoplastic combined chemotherapy protocols/therapeutic use treatment outcome randomized controlled trial |
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