| 凋亡抑制新基因Livin与宫颈癌的关系 |
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| 引用本文： | 徐小雨,赵凌云,唐劲天.凋亡抑制新基因Livin与宫颈癌的关系[J].国际肿瘤学杂志,2009,36(9). |
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| 作者姓名： | 徐小雨 赵凌云 唐劲天 |
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| 作者单位： | 1. 北京中医药大学中药学院生物制药系
2. 清华大学工程物理系粒子技术与辐射成像教育部重点实验室,北京,100084 |
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| 摘 要： | 凋亡蛋白抑制因子(IAP)是一类抑制凋亡的调节分子,其成员Livin是新发现的凋亡抑制基因,能够与内源IAP抑制剂SMAC和caspase-3、caspase-7、caspase-9结合,发挥抗细胞凋亡的作用.近年来,研究发现Livin在宫颈癌细胞及组织中高表达,而且通过检测癌细胞凋亡有助于确定宫颈癌的发生机制及其疗效评价,因此研究Livin结构与功能及作用机制对于宫颈癌的发生、发展、诊断与治疗有积极意义.
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| 关 键 词： | 宫颈肿瘤 基因 livin 细胞凋亡 |
Relationship between a novel anti-apoptosis gene livin and cervical cancer |
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| Abstract: | Inhibitor of apoptosis protein(IAP) is a kind of anti-apoptosis regulation molecule, Livin is a new member of the inhibitor of apoptosis protein family, It could bind the endogenous lAP antagonist SMAC and caspase -3, caspase -7 ,and caspase -9 to inhibit apopto-sis. Recently, Researches have demonstrated that Livin is highly expressed in the cervical cancer cells and tissue. And identifying occurrence mechanism of cervical cancer and its evaluation benefits from detection of cancer cells apoptosis, so research of its structure, function and mechanism will have important significance for the happen, development, diagnosis and therapy of cervical cancer. |
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| Keywords: | Cervix neoplasms Genes livin Apoptosis |
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