急性出血性脑卒中患者术后血清白细胞介素6与C-反应蛋白动态检测及其临床意义

目的:探讨在急性出血性脑卒中患者术后白细胞介素6和C-反应蛋白的变化规律和作用以及与病情转归的关系。方法:检测45例患者术后1天、3天、5天、7天、10天的白细胞介素6和C-反应蛋白的血清浓度,和对照组进行对比,同时记录发病时病情评分。结果:术后第一天血清白细胞介素6水平即达峰值,第三天呈下降趋势,第十天已基本恢复正常,血清C-反应蛋白延迟于白细胞介素6出现,第一天即升高,到第三天达峰值,以后逐步下降,与对照组比较,有显著性差异(P<0.01),二者增高程度都与病情密切相关(P<0.01)。结论:急性出血性脑卒中的患者术后血清白细胞介素6和C-反应蛋白的测定对判定脑组织损害轻重,机体免疫状态和临床上判定疗效和预后具有很重要的意义。

The Determination of Interlnterleukin-6 serum and C-reactive protein of patients after acute cerebral hemorrhage surgery

objects To investigate the role and the rule of Interleukin-6 and C-reactive protein of patients after acute-cerebral hemorrhage surgery and relation with the GCS. Methods The serm Interleukin-6 and C-reactive protein of 45 patients after acute cerebral hemorrhage surgery were determined and recorded the GCS sinultaneousty. Results the serum IL-6 level of the first day after surgery in acute cerebral hemorrhage patients were significantly higher than those in the normal control group (P<0.01). It descended on the 3rd, and recovered basically on the tenth day, and revealed that serum IL-6 levesl had significant correlation with the neurologicaldysfunction (P < 0.01). the serum C-reactive protein level of the first day after surgery wer signifcantly higher than those in the noral control group ( P< 0.01). and reached the top level on the third day which showed the negative correlation(P<0.01)with GCS. Conclusions Interleukin-6 and CRP may play a important role in the pathological process of acute cerebral hemorrhage. the determination of Interleukin-6 and CRP is valuable for the severity of stress and prediction of acute cerebral hemorrhage.