氯化甲基汞染毒对大鼠后代发育的影响

目的探讨甲基汞对雄性大鼠生殖功能的影响和通过父系传播对后代的影响。方法将20只Wistar雄性大鼠随机分为4组，分别给予0、0．058、0．580、1．170mg／kg体重的氯化甲基汞，以隔日经口灌胃的方式染毒，持续染毒2个月后，将其与健康雌性大鼠交配，观察仔鼠的生长发育与神经行为发育情况。结果1．170、0．580mg／kg组仔鼠体重低于对照组，其早期生长发育指标落后于对照组仔鼠；染毒组仔鼠转体时间延长、前肢悬挂时间缩短，与对照组相比，差异有统计学意义（P〈0．05）。观察组仔鼠平面翻正、断崖回避、空中翻正的正确率与对照组相比，也明显降低（P〈0．01或P〈0．05）。结论雄鼠甲基汞染毒后，可以影响仔鼠的生长发育和神经行为发育。

Effects of Methyl Mercury on the Development of Rat Offspring

Objective To study the effect of methyl mercury on the development of rat offspring. Methods The male Wistar rats were divided into four groups randomly, each group was administrated methyl mercury by gavage every two days for two months, then, the rats were mated with healthy female rats. The development, growth and behaviors of offspring were investigated. Results Compared with the control, the body weights of offspring in groups of 1.170 mg/kg and 0.580 mg/kg were less and the development was tardy. The indexes that can reflect the level of development showed that the behaviors of offspring in experimental groups were damaged. Conclusion The male rats exposed to methyl mercury may produce an adverse effect on the development, growth and behaviors of their offspring.