Peptide-urea interaction |
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Authors: | ATTILIO CESRO ELIO RUSSO GUIDO BARONE |
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Institution: | ATTILIO CESÀRO,ELIO RUSSO,GUIDO BARONE |
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Abstract: | The excess enthalpies of the ternary aqueous solutions containing urea and the glycyl-glycine, glycyl-L-alanine, L-alanyl-L-alanine and sarcosyl-sarcosine diketopiperazines respectively have been determined. A weak but favourable enthalpic contribution to the interaction between these solutes is found. The difference between “strong” and “weak” interactions in aqueous solutions of non-electrolytes is stressed and the role of water in the weak, non-specific interactions, is discussed. The consequence of the weakness of the urea-peptide interactions on the binding of urea to the proteins is also briefly discussed. |
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Keywords: | cyclic dipeptides denaturation diketopiperazines heat of mixing urea weak interactions |
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