| Abstract: | Determination of (1) the absolute number of cholinergic receptors, (2) the cholinergic binding kinetics, and (3) the direct antimuscarinic activity of a series of uropharmacologic agents was accomplished by radioligand binding techniques in tissue derived from human urinary bladder. The competition between 3H-quinuclidinyl benzilate (3H-QNB) binding and selective antagonists provided the first quantitative assessment of cholinergic receptor characteristics in the human bladder fundus and represents a potential method for assessing the antimuscarinic binding potential of uropharmacologic agents. |
