Melphalan-Related Leukemia in Multiple Myeloma |
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| Authors: | Anders Wahlin,G ran Roos,Olle Rudolphi,Jan Holm |
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| Affiliation: | Anders Wahlin,Göran Roos,Olle Rudolphi,Jan Holm |
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| Abstract: | ABSTRACT. Five patients with multiple myeloma ending in acute leukemia are described. The preleukemic phase was characterized by anemia, leukopenia and/or thrombocytopenia. The incidence of acute leukemia in myeloma was calculated to be 6%. Melphalan therapy for more than two years increased the incidence to 14%. All patients who developed leukemia had received a total melphalan dose of at least 1100 mg. |
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| Keywords: | multiple myeloma leukemia melphalan |
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