The Effect of Prednisone on Platelet Function Tests |
| |
Authors: | Kaj Anker Jrgensen Leif Freund Per Srensen |
| |
Institution: | Kaj Anker Jørgensen,Leif Freund,Per Sørensen |
| |
Abstract: | Ivy bleeding time, capillary fragility, threshold ADP concentration for secondary platelet aggregation and platelet adhesiveness were found to be unchanged by 2 d and 6 weeks of treatment with prednisone in 22 consecutive patients with collagen or haematological diseases. Initial high platelet counts were unchanged after 2 d of treatment, but fell significantly to normal values after 6 weeks of treatment. Initial high levels of factor Vlll-related antigen increased insignificantly following 2 d of treatment, but after 6 weeks of treatment the increase was significant. It is concluded that in patients of this category a 6-week treatment with commonly used doses of prednisone does not significantly affect platelet function. |
| |
Keywords: | bleeding time capillary fragility factor-VIII related antigen glucocorticosteroids platelet aggregation |
|
|