|
|||||
|
|
β-Endorphin: synthesis and properties of human β-endorphin-(1–28) and its analogs |
|
| Authors: | Raffaella Garzia Donald Yamashiro Choh Hao Li Pierre Nicolas |
| Abstract: | Three analogs of human β-endorphin (βh-EP) were synthesized by the solid-phase method: βh-EP-(1–28) (II), [D-Ala2, Gln8] - βh-EP-(1–28) (III). Radioreceptor binding assay with use of tritiated βh-EP as primary ligand gave relative potencies as follows: βh-EP, 100; I, 85; II, 380; III, 146. Relative potencies in an analgesic assay were: βh-EP; 100; I, 18; II, 36; III, 13. |
| Keywords: | opiate receptor-binding analgesia solid-phase peptide synthesis |