Proteinase-Activated Type 1 Receptors are Involved in the Mechanism of Protection of Rat Hippocampal Neurons from Glutamate Toxicity |
| |
| Authors: | L. R. Gorbacheva T. P. Storozhevykh E. V. Kiseleva V. G. Pinelis S. M. Strukova |
| |
| Affiliation: | (1) Laboratory of Membranology, Research Center of Child Health, Russian Academy of Medical Sciences, Russia;(2) Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |
| |
| Abstract: | Survival of cultured rat hippocampal neurons was estimated 4, 24, and 48 h after 15-min exposure to the toxic effect of glutamate under conditions of pre- or coincubation with 10 nM thrombin. Thrombin inhibited glutamate-induced apoptosis in neurons 24 and 48 h after treatment, but had no effect on necrosis. Selective peptide agonist of proteinase-activated type 1 receptors simulated, but receptor antagonist suppressed the neuroprotective effect of thrombin. Our results suggest that peptide antagonist of type 1 receptors play a role in the mechanisms of neuronal protection from glutamate toxicity. __________ Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 9, pp. 265–268, September, 2005 |
| |
| Keywords: | brain neurotoxicity glutamate thrombin proteinase-activated type 1 receptors |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
