| 利福霉素产生菌发酵培养基的研究 |
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| 引用本文： | 金玉坤,熊宗贵,白秀峰. 利福霉素产生菌发酵培养基的研究[J]. 沈阳药科大学学报, 1992, 0(2) |
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| 作者姓名： | 金玉坤 熊宗贵 白秀峰 |
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| 作者单位： | 沈阳药学院微生物制药教研室，沈阳药学院微生物制药教研室，沈阳药学院微生物制药教研室 研究生 正导师，研究生 副导师 |
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| 摘 要： | 本文考查了各种无机、有机氮源和黄豆饼粉酶解液对地中海诺卡氏菌(Nocardiamediterranei)C_(?)-8菌株生物合成利福霉素SV的影响。结果以蛋白胨、硝酸钾的效果为最佳。通过均匀设计的实验,获得了最佳发酵培养基的组成,使利福霉素SV的产量提高30%.
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| 关 键 词： | 利福霉素SV 发酵 均匀设计 |
STUDIES ON THE FERMENTATION MEDIUM OF NOCARDIA MEDITERRANEI PRODUCING RIFAMYCIN SV |
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| Jin Yukun Xiong Zonggui Bai Xiufeng. STUDIES ON THE FERMENTATION MEDIUM OF NOCARDIA MEDITERRANEI PRODUCING RIFAMYCIN SV[J]. Journal of Shenyang Pharmaceutical University, 1992, 0(2) |
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| Authors: | Jin Yukun Xiong Zonggui Bai Xiufeng |
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| Affiliation: | Jin Yukun Xiong Zonggui Bai Xiufeng Department of Microbial Pharmaceutics |
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| Abstract: | The effects of nitrogen from various inorganic and organic sources and enzyme hydrolysate of soya meal on rifamycin SV biosynthesis from Nocardia mediterranei Cs-8~* have been investigated. Results showed that peptone and KNO_3 were the best sources. The best medium was obtained through rational distribution design. The yield of rifamycin SV with optimum medium in shaking flask was 30% higher than that with the original strain and medium. |
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| Keywords: | Rifamycin SV Fermentation Rational distribution design |
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