| Sequentially releasing self-healing hydrogel fabricated with TGFβ3-microspheres and bFGF to facilitate rat alveolar bone defect repair |
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| 作者姓名： | Fenglin Yu Dezhi Geng Zhanpeng Kuang Shiyi Huang Yating Cheng Yini Chen Fang Leng Yu Bei Yueping Zhao Qingxia Tang Yadong Huang Qi Xiang |
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| 作者单位： | 1. Department of Cell Biology, College of Life Science and Technology, Jinan University;2. Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University;3. Biopharmaceutical R&D Center of Jinan University;4. Department of Stomatology, Jinan University Medical College |
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| 基金项目： | supported by grants from the Guangzhou Science and Technology Program Key Project (Grant No. 201803010044)；;Guangdong Province College Characteristic Innovation Project (2019KTSCX011)；;Guangdong Province Natural Sciences Fund Project (2021A1515012480)； |
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| 摘 要： | Resorption and loss of alveolar bone leads to oral dysfunction and loss of natural or implant teeth. Biomimetic delivery of growth factors based on stem cell recruitment and osteogenic differentiation, as the key steps in natural alveolar bone regenerative process, has been an area of intense research in recent years. A mesoporous self-healing hydrogel(DFH) with basic fibroblast growth factor(bFGF) entrapment and transforming growth factor β3(TGFβ3)-loaded chitosan microspheres(CMs) was develope...
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| 收稿时间： | 2021-09-15 |
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