IgM,IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors |
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Authors: | F Silvestris J S Goodwin R C Williams Jr |
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Institution: | (1) Department of Medicine, University of New Mexico School of Medicine, 87131 Albuquerque, New Mexico, USA;(2) School of Medicine, University of New Mexico, 87106 Albuquerque, New Mexico, USA |
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Abstract: | Summary IgM, IgA, and IgG Rheumatoid Factors (RF) were measured by ELISA assay in serum from 26 patients with definite rheumatoid arthritis (RA) and 11 normal controls. IgM-RF was assayed by ELISA, radioimmunoassay,and also by the standard latex fixation test in all sera from RA patients. In patients with RA quantitative amounts of IgM, IgA, and IgG-RF as estimated by ELISA were highly correlated. Significant correlations were found between a physician's rating of disease activity and IgG-RF (r=0.44; p<.02) and IgA-RF (r=0.38; p=.06 but not for IgM-RF as measured in any of the three assays.During the course of this work F.S. was supported by a NATO fellowship from the Consiglio Nazionale delle Ricerche, Roma, Italy. |
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Keywords: | Rheumatoid Factors ELISA Radioimmunoassay |
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