理血消银汤治疗银屑病临床疗效及对血浆内皮素的影响

目的观察理血消银汤治疗寻常型银屑病的临床疗效及对血浆内皮素（ET）的影响。方法将220例患者分为两组。治疗组118例口服理血消银汤，对照组102例口服复方青黛胶囊，疗程8周后评价其临床疗效；并用放免法检测治疗前后ET含量。结果两组效率分别为73．7％、54．9％，两组比较差异有显著性（X^2=8．52，P〈0．01）；银屑病患者血浆ET水平明显高于健康对照组，经治疗后两组ET均下降，治疗组下降更明显，与对照组比较差异有显著性（P〈0．01）。结论理血消银汤治疗银屑病有较好临床疗效，能改善微循环，抑制上皮细胞分裂，促进表皮细胞分化，对血浆ET有调节作用。

Therapeutic Efficacy of Lixue Xiaoyin Decoction in Treating Psoriasis and Its Effect on Plasma Edothelin

OBJECTIVE: To study the therapeutic efficacy of Lixue Xiaoyin Decoction (LXD) in treating psoriasis and its effect on plasma endothelin (ET). METHODS: Two hundred and twenty patients were divided into two groups. LXD was taken orally by the 118 patients in the treated group, while Compound Qingdai Capsule (CQC) taken orally by the 102 patients in the control group. The therapeutic efficacy was evaluated after 8 weeks of treatment. The ET content was determined by radioimmunoassay before and after treatment. RESULTS: The total effective rate was 73.72% in the treated group and 54.90% in the control group with significant difference (chi2 = 8.52, P < 0.01). The plasm ET level in patients was significantly higher than that in the healthy subjects. ET in both groups was all lowered after treatment, but the decrement was more obvious in the treated group, showing significant difference when compared with that in the control group (P < 0.01). CONCLUSION: LXD shows good therapeutic efficacy in the treatment of psoriasis. It can improve the microcirculation, inhibit the division of epithelial cells, promote the epidermic cell differentiation, and shows regulative effect on plasma ET.