肺癌基因治疗研究进展

1　抑癌基因　　肿瘤的形成是“癌基因”与“抑癌基因”这对矛盾的平衡被打破的结果 ,如癌基因放大或过度表达 ,抑癌基因失活都会导致癌变发生。抑癌基因有很多如ＴＰ5 3、ＲＢ、Ｐ1 6、Ｂａｘ等 ,其中ＴＰ5 3是最重要的抑癌基因 ,ＴＰ5 3功能的失活 ,引起抑癌活性丧失 ,促进细胞恶性转化。目前认为ＴＰ5 3基因抑制肿瘤除它直接诱导细胞凋亡外 ,还能诱导肿瘤局部产生ＴＮＦα、ＩＬ-6等炎性细胞因子 ,增强瘤细胞对放、化疗的敏感性。晚近还认为它能抑制肿瘤内ＶＥＧＦ表达 ,抑制肿瘤血管生成。ＴＰ5 3基因在大多恶性肿瘤中表现为突变或缺失 …

Progress in pulmonary carcinoma gene therapy

The high morbidity and mortality of pulmonary carcinoma,especially in male patient,are still the unsolved problems. Recently,more and more reports showed that gene therapy could have potential application in the treatment of the disease. In this article,some progresses in the gene therapy of pulmonary carcinoma, such as tumor suppressor gene,drug sensitive gene,antisense gene,multi-drug resistance gene,immune gene as well as anti-angiogenesis gene, were discussed.