相位对比电影MR成像评估婴幼儿脑血流特点

目的 采用相位对比电影MR成像(PC cine MRI)观察婴幼儿颈内动脉(ICA)血流动力学特点,评估脑血流量(CBF).方法 对37例婴幼儿行MR检查,以多个编码流速度PC cine MR序列测量ICA峰值流速(Vp)及血流量,计算单位体积CBF.采用Pea rson线性相关分析观察周龄与ICA Vp、ICA血流量...

Phase contrast cine MRI evaluation on characteristics of cerebral blood flow in infants and young children

Objective To observe the hemodynamics of the internal carotid artery (ICA) of infants and young children with phase contrast cine MRI (PC cine MRI), and to evaluate their cerebral blood flow (CBF). Methods Data of 37 infants and young children who underwent MR examination were retrospective analyzed. The peak velocity (V_P) and blood flow of ICA were measured using PC cine MR sequences with multiple velocity encodings, and unit volume CBF was calculated. The relationships between age (weeks) and ICA V_P, ICA blood flow, ICA diameter, CBF and brain volume, as well as between ICA V_P and ICA diameter, heart rate were analyzed with Pearson linear correlation. Results Age was found positively correlated with ICA blood flow, ICA diameter, CBF and brain volume (all P<0.01), negatively correlated with heart rate (P<0.01),but not correlated with ICA V_P (P=0.532).Among the fitting curves of age and CBF, R² of cubic polynomial was the highest (R²=0.612). There was no significant correlation of ICA V_p and ICA diameter, nor between ICA V_p and heart rate (both P>0.05). Conclusion PC cine MRI could be used to non-invasively observe the hemodynamics of ICA of infants and young children, providing information for quantitative evaluation on brain development.