基于肺磨玻璃结节CT征象的诊断模型列线图评估肺癌浸润性 |
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引用本文: | 郑慧,李建玉,王珊,钟飞扬,王彬宸,安文婷,廖美焱. 基于肺磨玻璃结节CT征象的诊断模型列线图评估肺癌浸润性[J]. 放射学实践, 2021, 36(4): 470-474 |
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作者姓名: | 郑慧 李建玉 王珊 钟飞扬 王彬宸 安文婷 廖美焱 |
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作者单位: | 430071 武汉武汉大学中南医院放射科 |
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基金项目: | 湖北省卫生健康委员会联合基金(WJ2019H066) |
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摘 要: | 目的:探讨CT影像征象鉴别磨玻璃结节(GGNs)型肺腺癌浸润程度的价值.方法:搜集2017年6月-2019年10月在本院行手术切除的166例GGNs样肺癌患者的病例资料,其中浸润前组24例、浸润组142例.比较两组间影像学特征的差异,通过二项logistic回归分析筛选浸润性肺癌的危险因素并建立联合诊断模型,利用ROC...
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关 键 词: | 磨玻璃结节 腺癌 浸润性 诊断模型 体层摄影术 X线计算机 列线图 |
Evaluation on the invasion of lung cancer by diagnostic model nomogram based on the CT characteristics of pulmonary ground glass nodules |
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Affiliation: | (Department of Radiology,the Zhongnan Hospital of Wuhan University,Wuhan 430071,China) |
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Abstract: | Objective:To explore the value of CT imaging characteristics in differentiating the infiltration degree of lung adenocarcinoma manifested as ground glass nodules(GGNs).Methods:From June 2017 to October 2019,the clinical data of 166 patients with pulmonary carcinoma appearing as ground-glass nodules(GGNs)confirmed by pathology were collected in this study.166 GGNs were divided into pre-invasion group(n=24)and invasion group(n=142).The difference of imaging characteristics between the two groups were compared and diagnostic model was then established by univa-riate analysis and multivariate logistic regression analysis.Receiver operating characteristic(ROC)curve were used to evaluate the diagnostic efficacy of CT features.Nomogram was used to quantify the independent risk factors.Results:The proportion of pure GGNs was higher in pre-invasion group.The imaging features of the two groups showed that the diameter of the pre-invasion group was smaller with lower density.The invasion group was more prone to appear as pleural changes,air bronchogram,vascular notch sign,vessel changes,spiculation and lobulation.Multivariate logistic regression analysis showed that vascular changes[odds ratio(OR)=4.319,P=0.01],spiculation(OR=3.664,P=0.016)and vascular notch sign(OR=3.36,P=0.047)were independent risk factors.ROC analysis revealed the AUC of the diagnostic model was 0.805(95%CI:0.713~0.898;P<0.05),with sensitivity of 62.0%and specificity of 87.5%.Nomogram analysis showed that C index of the three imaging features was 0.828(95%CI:0.732~0.924).Conclusion:Invasive GGNs are significantly associated with vascular changes,spiculation and vascular notch sign.The invasion diagnostic model based on CT imaging features is of good diagnostic efficacy.Nomogram is helpful for quantitative diagnosis. |
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Keywords: | Ground glass nodule Adenocarcinoma Invasive Diagnostic model Tomography,X-ray computed Nomogram |
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