Solitary fibrous tumour of the thyroid: Clinicopathological,immunohistochemical and ultrastructural study of three cases |
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| Authors: | Gianluca Taccagni Clara Sambade Jahn Nesland Maria Rosa Terreni Manuel Sobrinho-Simões |
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| Institution: | (1) Department of Pathology, University of Milan, San Raffaele Hospital, Milan, Italy;(2) Department of Pathology, Medical Faculty, University of Porto, Hospital S. João, Porto, Portugal;(3) Department of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, Oslo, Norway;(4) Cattedra di Anatomia e Istologia Patologica, Istituto Scientifico H S. Raffaele, Università degli Studi di Milano, via Olgettina 60, I-20132 Milano, Italy |
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| Abstract: | We describe three cases of solitary fibrous tumour (SFT) arising from thyroid stroma. Grossly, the tumours were clearly delimited but only partly encapsulated. The following histomorphological growth patterns were observed: bundles of cells in storiform configuration; non-structured bundles; prevalence of fibrous matrix; highly cellular, non-structured; prevalence of loose, non-structured extracellular substance; cellular proliferation and vascular spaces in a haemangiopericytic configuration and a lipomatous component. Immunohistochemical investigation demonstrated intense, diffuse vimentin positivity and focal, less intense actin positivity in all three cases. At electron microscopy we observed a primitive cell of mesenchymal type, with cytoplasm poor in organelles and rich in filaments; this cell sometimes presented differentiation characteristics. SFT is at present the most correct term for the lesions presented here despite some morphological characteristics which differ from cases reported in the literature. |
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| Keywords: | Solitary fibrous tumour Mesenchymal tumour Thyroid Immunohistochemistry Electron microscopy |
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