Graves眼病患者血清中IL-4及TNF-α的表达

目的：探讨细胞因子对Graves眼病（GO）的影响。方法：检测45例Graves病（GD）非突眼患者、36例GO患者及36例正常对照者血清中TNF-α及IL-4的表达水平和甲状腺激素水平。结果：GD组和GO组患者TNF-α、IL-4显著高于对照组。GO组TNF-α/IL-4比值与对照组比较无显著性差异。结论：GD非突眼患者以IL-4升高为主,提示Th2介导的体液免疫占优势;GO患者的免疫反应呈Th0型,细胞和体液免疫共同参与GO的发生。

Expressions of serum IL-4 and TNF-α in patients with Graves ophthalmopathy

Objective： To investigate the effect of cytokines on the Graves ophthalmopathy （GO）. Methods： The level of TNF-α, IL-4 and thyroid hormone were determined in 45 patients with Graves disease （GD） but without phthalmopathy, 36 patients with Graves ophthalmopathy and 36 control subjects. Results： The levels of TNF-α and IL--4 in GD and GO group were significantly higher than that in control group. TNF-α/IL-4 ratio showed no significant difference between the GO group and control group. Conclusion： The patients with GD mainly display an increase of IL-4, indicating that the Th2-mediated humoral immunity plays a predominant role in patients with GD but without ophthalmopathy. A Th0-type immune response may be presented in patients with GO, and both cellular and immune response play a role in the development of GO.