Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine |
| |
Authors: | Belsem Marzouk Zohra Marzouk Rachel Dcor Hayet Edziri Ehsen Haloui Nadia Fenina Mahjoub Aouni |
| |
Institution: | Belsem Marzouk, Zohra Marzouk, Rachel Décor, Hayet Edziri, Ehsen Haloui, Nadia Fenina,Mahjoub Aouni, |
| |
Abstract: | Ethnopharmacological relevanceResistance to current antibacterial drugs and the rise of opportunistic fungal infections are growing global concerns. Traditional medicine is a potential source of new antibacterials and antifungals. Citrullus colocynthis Schrad. (Cucurbitaceae) endemic in Southern Tunisia, is used in folk medicine against dermatological, gynaecological and pulmonary infections.Aim of studyTo assess in vitro antibacterial and anticandidal activity of aqueous and diluted acetone extracts of Citrullus colocynthis Schrad. MIC and MBC/MFC were determined for plant organs at different maturation stages.Materials and methodsCitrullus colocynthis Schrad. was harvested and its identification was verified. Aqueous and diluted acetone extracts (from the plant's roots, stems, leaves and three maturation stages of its fruit and seeds) were screened for activity against Gram-negative and Gram-positive bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis)—and various Candida spp. (Candida glabrata, Candida albicans, Candida parapsilosis and Candida kreusei).ResultsAll extracts showed activity against all strains. The highest MICs and MBCs/MFCs were obtained from the fruit aqueous extracts (MIC 0.10 mg/ml against Candida albicans and Candida glabrata, 0.20 mg/ml against Escherichia coli and Pseudomonas aeruginosa), lowest activity from the root extracts.ConclusionsCitrullus colocynthis Schrad. shows antibacterial and anticandidal properties. The folk medicinal use as a broad-spectrum antimicrobial agent is validated. |
| |
Keywords: | Citrullus colocynthis Schrad Aqueous extract Acetone extract Antibacterial Anticandidal Tunisia |
本文献已被 ScienceDirect 等数据库收录! |
|