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Structure elucidation and conformational study of V8: a novel synthetic non peptide AT(1) antagonist |
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| Authors: | Zoumpoulakis Panagiotis Politi Aggeliki Grdadolnik Simona Golic Matsoukas John Mavromoustakos Thomas |
| Affiliation: | aNational Hellenic Research Foundation, 48 Vas. Constantinou Ave. 11635, Athens, Greece bDepartment of Chemistry, University of Patras, Rio, Greece cNational Institute of Chemistry, Hajdrihova 19 P.O. Box 30 SI-1115, Ljubljana, Slovenia |
| Abstract: | AT1 antagonists constitute the most recent class of antihypertensive drugs which act through the Renin Angiotensin System (RAS). In an effort to comprehend their stereoelectronic features, a study was initiated to compare the conformational properties of drugs already marketed for the treatment of hypertension with synthetic ones, possessing common structural characteristics. In this study, the synthetic AT1 antagonist V8 is structurally elucidated and its conformational properties are studied through a combination of NMR spectroscopy and computational analysis. Its conformational properties are compared with those of the structurally similar prototype AT1 antagonist losartan. |
| Keywords: | Synthetic angiotensin II antagonists Conformational properties Molecular modeling NMR Losartan |
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