Airway involvement in inflammatory bowel disease: Inflammatory bowel disease patients have bronchial wall thickening |
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| Affiliation: | 1. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;3. Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan;4. Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan;1. Department of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, Kyoto, Japan;2. Department of Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan;3. Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;4. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;5. Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;1. Department of Medical Oncology, Kishiwada City Hospital, Japan;2. Department of Medical Oncology, Kindai University Faculty of Medicine, Japan;3. Department of Respiratory Medicine, Kishiwada City Hospital, Japan;4. Department of Radiation of Oncology, Kishiwada City Hospital, Kishiwada City Hospital, Japan;1. Department of Endoscopy, Respiratory Endoscopy Division. National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo, Tokyo, 104-0045, Japan;2. Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan;3. Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo, Tokyo, 104-0045, Japan;1. Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan;2. Department of Radiology, Saitama Medical University, Saitama, Japan;3. Department of Nutrition and Metabolism, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan;4. Faculty of Nutrition, Kagawa Nutrition University, Saitama, Japan;5. Sports Medicine Research Center, Keio University, Yokohama, Japan |
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| Abstract: | BackgroundRecent epidemiological studies have revealed a high co-occurrence of asthma or COPD and IBD. Herein, we examined the impact of IBD on the bronchial wall structure using three-dimensional computed tomography (3D-CT).MethodsSubjects who were diagnosed with IBD and had undergone chest CT were recruited from consecutive medical records. Screening chest CT scan data during the same period were used as normal controls. Airway dimensions were measured by validated software.ResultsOverall, 136 IBD and 99 control subjects were recruited. The bronchial walls of patients with IBD were significantly thicker than those of control subjects. Multiple linear regression analysis showed that Crohn's disease and ulcerative colitis were independent determinants of wall area percentage after adjusting for age, sex, and smoking status.ConclusionsAirway walls in patients with IBD were thicker than those in normal control subjects. Airway involvement in IBD may be more frequent than recognized. |
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| Keywords: | Inflammatory bowel disease Airway disease Airway wall 3D-CT IBD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" inflammatory bowel disease CT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" computed tomography CD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" Crohn's disease UC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" ulcerative colitis ARDS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" acute respiratory distress syndrome WT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" airway wall thickness WA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" airway wall area |
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