The prognostic value of the COPD Assessment Test in fibrotic interstitial lung disease期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The prognostic value of the COPD Assessment Test in fibrotic interstitial lung disease

Institution:	1. Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan;2. Department of Medical IT Center, Nagoya University Hospital, Nagoya, Aichi, Japan;3. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan;1. Department of Respiratory Medicine, St. Luke''s International Hospital, Tokyo, Japan;2. Department of Thoracic Surgery, Thoracic Center, St. Luke''s International Hospital, Tokyo, Japan;1. Department of Respiratory Medicine, Okayama City Hospital, 3-20-1, Kitanagaseomote-cho, Kita-Ku, Okayama, 700-8557, Japan;2. Department of Allergy and Respiratory Medicine, National Hospital Organization, Minami Okayama Medical Center, 4066 Hayashima, Hayashima-cho Tsukubo-gun, Okayama, 701-0304, Japan;1. Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya, Japan;2. Department of Education and Research Center for Community Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;1. Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan;2. Department of Pharmacy, Kobe Tokushukai Hospital, Kobe, Japan;3. Department of Emergency Medicine and Critical Care Medicine, Tochigi Prefectural Emergency and Critical Care Centre, Imperial Foundation Saiseikai Utsunomiya Hospital, Tochigi, Japan;4. Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan;5. Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan;6. Department of Emergency and Critical Care Medicine, Shimane University, Shimane, Japan;7. Intensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan;8. Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine, Tokyo, Japan;9. Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan;10. Department of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;11. Preventive Services, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan;1. Department of Respiratory Medicine, Tokyo Women''s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan;2. Department of Genomic Medicine, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan;3. Department of Central Laboratories, Mie University Hospital, 2-174 Edobashi, Tsu, Mie 514-8507, Japan;4. Department of Otorhinolaryngology, Head & Neck Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

Abstract:	BackgroundThe COPD Assessment Test (CAT) has been studied as a measure of health status in idiopathic pulmonary fibrosis (IPF) and interstitial lung disease associated with connective tissue disease. However, its prognostic value is unknown. The present study explored the association between CAT score and mortality in fibrotic interstitial lung disease (FILD), including IPF and other forms of ILD.MethodsWe retrospectively analyzed 501 consecutive patients with FILD who underwent clinical assessment, including pulmonary function test and CAT. The association between CAT score and 3-year mortality was assessed using Cox proportional hazard analysis, Kaplan–Meier plots, and the log-rank test for trend. To handle missing data, the imputed method was used.ResultsThe patients’ median age was 68 years, and 320 were male (63.9%). Regarding CAT severity, 203 patients had a low impact level (score <10), 195 had a medium level (10–20), 80 had a high level (21–30), and 23 had a very high level (31–40). During the 3-year study period, 118 patients died. After adjusting for age, sex, forced vital capacity, diffusion capacity for carbon monoxide, IPF diagnosis, and usual interstitial pneumonia pattern on high-resolution computed tomography, the CAT score was significantly associated with 3-year mortality (hazard ratio in increments of 10 points: 1.458, 95% confidence interval 1.161–1.830; p < 0.001). In addition, patients with high and very high impact levels had twofold and threefold higher mortality risk than those with low levels, respectively.ConclusionThe CAT has prognostic value in FILD.

Keywords:	Health status Fibrotic interstitial lung disease Prognosis Idiopathic pulmonary fibrosis COPD Assessment Test 6MWD"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"6-min walk distance 6MWT"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"6-min walk test CAT"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"COPD assessment test CHP"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"chronic hypersensitivity pneumonitis COPD"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"chronic obstructive pulmonary disease CTD-ILD"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"connective tissue disease associated interstitial lung disease diffusion capacity of the lung for monoxide forced expiratory volume in 1 second FVC"} {"#name":"keyword" "$":{"id":"kwrd0120"} "$$":[{"#name":"text" "_":"forced vital capacity HADS"} {"#name":"keyword" "$":{"id":"kwrd0130"} "$$":[{"#name":"text" "_":"hospital anxiety and depression scale HRCT"} {"#name":"keyword" "$":{"id":"kwrd0140"} "$$":[{"#name":"text" "_":"high-resolution computed tomography HRQOL"} {"#name":"keyword" "$":{"id":"kwrd0150"} "$$":[{"#name":"text" "_":"health-related quality of life ILD-GAP"} {"#name":"keyword" "$":{"id":"kwrd0160"} "$$":[{"#name":"text" "_":"interstitial lung disease-gender age"} {"#name":"keyword" "$":{"id":"kwrd0170"} "$$":[{"#name":"text" "_":"and physiological variables IPF"} {"#name":"keyword" "$":{"id":"kwrd0180"} "$$":[{"#name":"text" "_":"idiopathic pulmonary fibrosis LTOT"} {"#name":"keyword" "$":{"id":"kwrd0190"} "$$":[{"#name":"text" "_":"long term oxygen therapy MMRC"} {"#name":"keyword" "$":{"id":"kwrd0210"} "$$":[{"#name":"text" "_":"modified Medical Research Council NSIP"} {"#name":"keyword" "$":{"id":"kwrd0220"} "$$":[{"#name":"text" "_":"non-specific interstitial pneumonia PROs"} {"#name":"keyword" "$":{"id":"kwrd0230"} "$$":[{"#name":"text" "_":"patient-reported outcomes SGRQ"} {"#name":"keyword" "$":{"id":"kwrd0240"} "$$":[{"#name":"text" "_":"St George's Respiratory Questionnaire oxygen saturation measured by pulse oximetry UC-ILD"} {"#name":"keyword" "$":{"id":"kwrd0260"} "$$":[{"#name":"text" "_":"unclassifiable interstitial lung disease
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