Smart drug delivery systems for precise cancer therapy |
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| Institution: | 1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;2. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;3. School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China;4. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;5. Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China;6. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;7. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China;8. School of Life Sciences, Jilin University, Changchun 130012, China |
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| Abstract: | Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics profiles, and in vivo distributions of anticancer nano-drug delivery systems. However, problems still exist in the delicate balance between improved anticancer efficacy and reduced toxicity to normal tissues, and opportunities arise along with the development of smart stimuli-responsive delivery strategies. By on-demand responsiveness towards exogenous or endogenous stimulus, these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner. Meanwhile, the blossom of nanotechnology, material sciences, and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics, versatile functions, and modification possibilities. This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems. It may provide references for researchers in the fields of drug delivery, biomaterials, and nanotechnology. |
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| Keywords: | Pharmaceutics Smart drug delivery system Stimuli-responsive Receptor-ligand-based delivery Nano-drug delivery systems Precise therapy Toxicity Cancer |
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