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Recurrence of idiopathic pulmonary hemosiderosis in adults with childhood onset: A case report and literature review
Affiliation:1. Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan;2. Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8520, Japan;3. Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8520, Japan;1. Department of Medical Oncology, Izumi City General Hospital, 4-5-1 Wake, Izumi, Osaka, 594-0073, Japan;2. Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2, Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan;3. Department of Hematology, Izumi City General Hospital, 4-5-1, Wake, Izumi, Osaka, 594-0073, Japan;4. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2-L5 Yamadaoka, Suita, Osaka, 565- 0871, Japan;5. Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan;6. Department of Diagnostic Pathology, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji-shi, Tokyo, 193-0998, Japan;7. Department of Pathology, Keiyu Hospital, 3-7-3 Minatomirai Nishi-ku, Yokohama-shi, Kanagawa, 220-8521, Japan;8. Department of Pathology, School of Medicine, International University of Health and Welfare, 1-4-3 Mita, Minato-ku, Tokyo, 108-8329, Japan;1. Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan;2. Department of Pulmonary Immunotherapeutics, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan;3. Internal Medicine, Kudanzaka Hospital, 1-6-12 Kudan-minami, Chiyoda-ku, Tokyo, 102-0074, Japan;1. Department of Respiratory Medicine, St. Luke''s International Hospital, Tokyo, Japan;2. Department of Thoracic Surgery, Thoracic Center, St. Luke''s International Hospital, Tokyo, Japan;1. Department of Pediatrics, Tokai University School of Medicine, Japan;2. Department of Pediatrics, Tokai University Hachioji Hospital, Japan;3. Department of Respiratory Medicine, Tokai University Hachioji Hospital, Japan;1. Division of Pulmonary, Critical Care and Sleep Medicine, Stanford University, USA;2. imvaria inc., USA;3. Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, USA
Abstract:We describe a rare case of a 20-year-old Japanese man with idiopathic pulmonary hemosiderosis (IPH) recurrence in adults with childhood onset (racIPH). IPH commonly occurs in children, and data regarding racIPH are lacking. A review of the literature showed that only five cases of racIPH have been reported (including the present case) and that racIPH shows features that are intermediate between childhood- and adult-onset IPH with respect to age and a lower frequency of smoking history. We also found that the degree of anemia was usually not severe, and a favorable response to corticosteroid therapy is expected in racIPH.
Keywords:Idiopathic pulmonary hemosiderosis  Adult  Recurrence  Nonspecific interstitial pneumonia  Pulmonary fibrosis  aIPH"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  adult-onset idiopathic pulmonary hemosiderosis  cIPH"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0050"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  child-onset idiopathic pulmonary hemosiderosis  IPH"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0060"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  idiopathic pulmonary hemosiderosis  racIPH"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0070"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  idiopathic pulmonary hemosiderosis recurrence in adults with childhood onset
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