A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes |
| |
Affiliation: | 1. School of Pharmaceutical Science, Jinan University, Guangzhou 510006, China;2. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;3. Micromeritics Instrument (Shanghai) Ltd., Shanghai 200135, China;4. MEGGLE Group Shanghai Representative Office, Shanghai 201315, China;5. Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China |
| |
Abstract: | Dry powder inhalers (DPIs) had been widely used in lung diseases on account of direct pulmonary delivery, good drug stability and satisfactory patient compliance. However, an indistinct understanding of pulmonary delivery processes (PDPs) hindered the development of DPIs. Most current evaluation methods explored the PDPs with over-simplified models, leading to uncompleted investigations of the whole or partial PDPs. In the present research, an innovative modular process analysis platform (MPAP) was applied to investigate the detailed mechanisms of each PDP of DPIs with different carrier particle sizes (CPS). The MPAP was composed of a laser particle size analyzer, an inhaler device, an artificial throat and a pre-separator, to investigate the fluidization and dispersion, transportation, detachment and deposition process of DPIs. The release profiles of drug, drug aggregation and carrier were monitored in real-time. The influence of CPS on PDPs and corresponding mechanisms were explored. The powder properties of the carriers were investigated by the optical profiler and Freeman Technology four powder rheometer. The next generation impactor was employed to explore the aerosolization performance of DPIs. The novel MPAP was successfully applied in exploring the comprehensive mechanism of PDPs, which had enormous potential to be used to investigate and develop DPIs. |
| |
Keywords: | Dry powder inhaler Carrier particle size Pulmonary delivery process Real-time monitor Quick detection AE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" aerated energy APIs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" active pharmaceutical ingredients AR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" aeration ratio BFE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" basic flow Energy CFD-DEM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" computational fluid dynamics-discrete element method C.OPT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" optical concentration CPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" carrier particle size aerodynamic diameter DPIs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" dry powder inhalers the volume percentage of particles within certain range ED" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" emitted dose EDXS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" energy-dispersive X-ray spectroscopy centrifugal force drag force friction force gravity interaction force press-on force FPD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0220" }," $$" :[{" #name" :" text" ," _" :" fine particle dose FPF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0230" }," $$" :[{" #name" :" text" ," _" :" fine particle fraction FT4" },{" #name" :" keyword" ," $" :{" id" :" kwrd0240" }," $$" :[{" #name" :" text" ," _" :" Freeman Technology 4 HPLC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0250" }," $$" :[{" #name" :" text" ," _" :" high performance liquid chromatography HPMC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0260" }," $$" :[{" #name" :" text" ," _" :" hydroxypropyl methyl cellulose LAC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0270" }," $$" :[{" #name" :" text" ," _" :" lactose MFV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0280" }," $$" :[{" #name" :" text" ," _" :" minimum fluidization velocity MMAD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0290" }," $$" :[{" #name" :" text" ," _" :" mass median aerodynamic diameter MOC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0300" }," $$" :[{" #name" :" text" ," _" :" micro orifice collector MPAP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0310" }," $$" :[{" #name" :" text" ," _" :" modular process analysis platform MSS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0320" }," $$" :[{" #name" :" text" ," _" :" micronized salbutamol sulfate NGI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0330" }," $$" :[{" #name" :" text" ," _" :" Next Generation Impactor O" },{" #name" :" keyword" ," $" :{" id" :" kwrd0340" }," $$" :[{" #name" :" text" ," _" :" oxygen PD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0350" }," $$" :[{" #name" :" text" ," _" :" pressure drop PDP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0360" }," $$" :[{" #name" :" text" ," _" :" pulmonary delivery process PSF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0370" }," $$" :[{" #name" :" text" ," _" :" particle size fractions total release amount maximum of release amount release amount stopping distance SE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0420" }," $$" :[{" #name" :" text" ," _" :" specific energy SEM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0430" }," $$" :[{" #name" :" text" ," _" :" scanning electron microscope SSA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0440" }," $$" :[{" #name" :" text" ," _" :" specific surface area terminal time time TE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0480" }," $$" :[{" #name" :" text" ," _" :" total engery air flow rate velocity |
本文献已被 ScienceDirect 等数据库收录! |
|