GeneXpert MTB/RIF Version G4 for Identification of Rifampin-Resistant Tuberculosis in a Programmatic Setting |
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| Authors: | Muhammad Osman John A. Simpson Judy Caldwell Marlein Bosman Mark P. Nicol |
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| Affiliation: | aCity Health Directorate, City of Cape Town, South Africa;bNational Health Laboratory Services, Cape Town, South Africa;cUniversity of Cape Town, Medical Microbiology, Cape Town, South Africa;dNational Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa |
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| Abstract: | A recent Cochrane review estimated GeneXpert MTB/RIF specificity for rifampin resistance as 98% (95% confidence interval [CI], 97 to 99), based on results from earlier test versions. The measured positive predictive value of the new generation test from programmatic implementation in Cape Town, South Africa, was 99.5% (95% CI, 98.5 to 100), confirming excellent specificity. |
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