| 摘 要： | Chromosomal fragile sites studies were performed in 40 patients with lymphoma and 30 individuals as healthy controls. The results showed that there was a statistical difference of chromosomal aberration between the two groups; The patients carried 46 fragile sites totally; 21 out of 46 fragile sites in lymphoma corresponded with cancer breakpoints, and 9 fragile sites were located in the bands where oncogenes exist. These suggest a certain association between fragile sites, cancer breakpoints and oncogenes and thus indicate a possible important role of fragile sites in the pathogenesis of lymphoma.
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