| 雷公藤红素对白血病细胞Akt信号通路的影响及在细胞凋亡中的作用 |
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| 引用本文： | 王晓南,吴青,杨旭,张连生,吴一品,卢聪. 雷公藤红素对白血病细胞Akt信号通路的影响及在细胞凋亡中的作用[J]. 中国中西医结合杂志, 2011, 31(2): 228-232 |
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| 作者姓名： | 王晓南 吴青 杨旭 张连生 吴一品 卢聪 |
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| 作者单位： | 1. 武汉科技大学医学院,武汉,430000
2. 华中科技大学附属协和医院血液病研究所,武汉,430022 |
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| 基金项目： | 湖北省教育厅基金资助项目(No.B20101107) |
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| 摘 要： | 目的 研究雷公藤红素（celastrol)对人类白?∠赴闗562细胞Akt信号通路的影响及其作用。
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| 关 键 词： | 雷公藤红素；K562细胞；Akt；Caspase-3；Caspase-8 |
Effect of Celastrol on Akt Signaling Pathway and Apoptosis of Leukemic K562 Cell Line |
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| WANG Xiao-nan,WU Qing,YANG Xu,et al Medical College,Wuhan University of Science,Technology,Wuhan. Effect of Celastrol on Akt Signaling Pathway and Apoptosis of Leukemic K562 Cell Line[J]. Chinese journal of integrated traditional and Western medicine, 2011, 31(2): 228-232 |
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| Authors: | WANG Xiao-nan WU Qing YANG Xu et al Medical College Wuhan University of Science Technology Wuhan |
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| Affiliation: | WANG Xiao-nan,WU Qing,YANG Xu,et al Medical College,Wuhan University of Science and Technology,Wuhan (430000) |
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| Abstract: | Objective To research the effect and route of celastrol on Akt signaling pathway of human leukemia cell line K562 apoptosis. Methods The activities of K562 proliferation cells were detected by MTT assay; cell apoptosis was detected by Hoechst 33258 staining assay,DNA fragmentation assay,and Annexin V/PI double-labeled cytometry; the expression and phosphorylation level of Caspase family members and AKT signaling pathway related proteins were determined by Western blot before and after celastrol treatment,an... |
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| Keywords: | celastrol K562 cell Akt Caspase-3 Caspase-8 |
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