Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor |
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Authors: | Hillerns Pablo Ibieta Wink Michael |
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Institution: | Institut für Pharmazie und Molekulare Biotechnologie, Universit?t Heidelberg, Germany. |
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Abstract: | Prenylflavonoids and lavandulylflavonoids were isolated from the roots of Sophora flavescens Aiton (Fabaceae). The ability of 8-prenylkaempferol (1), kushenol X (2), norkurarinone (3), leachianone A (4), kushenol C (5), maackiain (6) and a root-extract of S. flavescens to displace 17beta-estradiol (E2) from rat uterine estrogen receptor (ER) was determined. Relative binding affinities (RBA) of prenylated flavonoids were weak with RBA values between 0.004 and 0.072. A lavandulyl or prenyl group at the position 8 enhanced binding to rat uterine ER. |
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