慢性乙型肝炎肝损伤患者临床特征与e抗原的关系

目的：对轻度及中度肝损伤的e抗原（Hepatitis Be antigen，HBeAg）阳性慢性乙型肝炎（chronic hepatitis B，CHB）和e抗原阴性CHB患者的临床特征进行比较。方法：对44例HBeAg阳性CHB和36例HBeAg阴性CHB进行病史询问，检测肝功能、血常规、血清乙型肝炎病毒（HBV）免疫学标志和HBVDNA，并进行腹部B超检查。结果：HBeAg阳性CHB组和HBeAg阴性CHB组在性别构成比例、HBV感染阳性家族史和肝脾肿大方而差异尤显著意义（P〉0．05）。HBeAg阳性CHB组和HBeAg阴性CHB组平均年龄分别为（29．23±8．246）岁和（41．53±13．146）岁（P〈0．001）；HBV感染年限≥5年者分别占36．36％和63．89％（P〈0．05）：HBVDNA滴度对数值平均为8．27±1．328和6．02±1．536（P〈0．01）。结论：在2组患者肝功能、血常规等临床特征一致的情况下，HBeAg阴性CHB患者有年龄偏大、感染年限较长和HBVDNA滴度较低的特点。

The Relation of Clinical Characters of Chronic Hepatitis B Patients with Liver Injury to Antigen e

Objective： To compare the clinical features of chronic hepatitis B （CHB） between types of Hepatitis B e antigen （HBeAg） positive and HBeAg negative. Methods： Investigation on 44 CHB patients with positive HBeAg （HBe-P） and 36 CHB patients with negative HBeAg （HBe-N） were carried out including asking disease histories, checking liver function, testing blood routine, and detection of HBV immunological marks and HBV DNA. Results： No significant difference was found in sex, family history of HBV positive infection, or splenohepatomegalia between groups HBe-P and HBeN, of which the average patient age were 29.23 ± 8. 246 and 41.53 ± 13. 146 （P 〈 0. 001 ） , the percent of patients with disease period longer than 5 years were 36.36% and 63.89% （P 〈0.05 ） , and the average HBV DNA titre logarithm were 8.27 ±1. 328 and 6.02 ±1. 536 （P 〈0. 001 ） respectively. Conclusions： Given similar clinical conditions such as same liver function level and blood routine indexes, CHB patients with negative HBeAg have older age, longer disease period, and lower HBV DNA titer than those of CHB patients with positive HBeAg.