| F30066的某些药理作用 |
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| 引用本文： | 唐瑞珍,邵葆若,谢蓉蓉.F30066的某些药理作用[J].药学学报,1964,11(7):450-453. |
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| 作者姓名： | 唐瑞珍 邵葆若 谢蓉蓉 |
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| 作者单位： | 中国医学科学院寄生虫病研究所 上海 |
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| 摘 要： | F30066对家兔胃肠道有强烈的刺激作用;对小白鼠的中枢神经系统与戊巴比妥钠有协同作用,也与五甲烯四氮唑有协同作用。它能使正常家兔的体温下降,使离体兔心收缩力减弱,使豚鼠小支气管平滑肌收缩。中毒家兔临死时四肢麻痹、呼吸减慢、角膜反射消失、交替出现强直性及阵攣性痉攣,最后因呼吸停止而死亡。一只中毒家兔于呼吸减慢前出现心跳不规律。
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| 收稿时间： | 1963-04-07 |
SOME PHARMACOLOGICAL ACTIONS OF F30066 |
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| TANG RUI-ZHEN SHAG BAG-RUG XEI RONG-RONG.SOME PHARMACOLOGICAL ACTIONS OF F30066[J].Acta Pharmaceutica Sinica,1964,11(7):450-453. |
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| Authors: | TANG RUI-ZHEN SHAG BAG-RUG XEI RONG-RONG |
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| Abstract: | F30066 caused severe gastro-intestinal irritation and lowered body temperature in normal rabbits. It potentiated both the stimulant effect of cardiazol and the depressant effect of sodium pentobarbital on central nervous system of mice. In isolated rabbit's heart, F30066 decreased the contractility. Experiments on perfused guinea pig lung indicated that F30066 constricted bronchioles. The signs of acute poisoning in rabbits consisted of paralysis of limbs, respiratory depression, and convulsions. One rabbit suffering from acute poisoning exhibited cardiac arrhythmia. |
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