Formulation and in Vitro–in Vivo Evaluation of Buccoadhesive Morphine Sulfate Tablets |
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| Authors: | Anlar Şule Çapan Yilmaz Güven Olgun Göğüş Ahmet Dalkara Turgay Hincal Atillâ |
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| Affiliation: | (1) Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey;(2) Department of Chemistry, Hacettepe University, Beytepe, 06532 Ankara, Turkey;(3) Department of Psychiatry, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey;(4) Department of Neurology, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey |
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| Abstract: | Buccoadhesive controlled-release systems for the delivery of morphine sulfate were prepared by compression of hydroxypropyl methylcellulose (HPMC) with carbomer (CP), which served as the bioactive adhesive compound. The release behavior of systems containing 30 mg of morphine sulfate and various amounts of the two polymers was found to be non-Fickian. The adhesion force was significantly affected by the mixing ratio of HPMC and CP in the tablet, and the weakest adhesion force was observed at a ratio of 1:1 (HPMC:CP). Interpolymer complex formation was confirmed between HPMC and CP in acidic medium by turbidity, viscosity, and FT-IR measurements. The amount absorbed (percentage of the drug loaded) of the controlled-release buccoadhesive tablets in six healthy volunteers and was 30 ± 5%. |
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| Keywords: | morphine buccoadhesion compressed tablet inter-polymer complex buccal absorption |
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