SEPARATION OFDL-DOPA BY MEANS OF MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY AFTER DERIVATIZATION WITH MARFEY'S REAGENT |
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| Authors: | GUANG WU MARIO FURLANUT |
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| Affiliation: | Institute of Clinical Pharmacology and Toxicology, Chair of Special Pharmacology, Medical School, University of Udine, Italy |
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| Abstract: | Micellar electrokinetic capillary chromatography was used to separate levodopa (L-3,4-dihydroxyphenyl-L-alanine), dextrodopa (D-3,4-dihydroxyphenyl-L-alanine) andDL-3-O-methyl-dopa, a metabolite of dopa, which were derivatised with the Marfey's reagent, in sodium borate, sodium dodecyl sulfate and acetonitile buffer system. WhereasDL-dopa derivatives could be separated,DL-3-O-methyl-dopa derivatives could not. |
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| Keywords: | levodopa dextrodopa font-variant: small-caps" >dl-3-O-methyl-dopa micellar electrokinetic capillary chromatography |
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