Plasma levels of 8-methoxypsoralen in psoriatic patients receiving topical 8-methoxypsoralen |
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| Authors: | V.S. NEILD L.V. SCOTT |
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| Affiliation: | Department of Dermatology, The London Hospital, Whitechapel, London E1 1BB;Department of Pharmacy, The London Hospital, Whitechapel, London E1 1BB |
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| Abstract: | Using a high-pressure liquid chromatographic technique, plasma psoralen levels have been measured in patients receiving total-body topical photochcmothcrapy (PUVA). Levels comparable with those found during oral 8-methoxypsoralen (8-MOP) treatment were observed, suggesting that topical therapy has no advantage over the oral route as far as the hazards of systemic therapy are concerned. |
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