不同治法对激素性股骨头坏死生化代谢影响的实验研究

目的：比较不同治法对激素性股骨头缺血性坏死的防治效果。方法：实验动物激素造模，分别喂服活血化瘀、渗湿化痰和补肾壮骨中药或自来水，6周处死取材，进行生化测定。结果：中药可对抗激素的作用，减轻骨钙丢失和骨基质合成减少的程度，提高血清钙的含量和钙、磷乘积水平。其中活血化瘀法效果明显优于渗湿化痰法和补肾壮骨法。结论：活血化瘀中药可促进生化代谢，纠正负钙平衡，促进基质合成和钙磷沉积。

Experimental Study of the Effect on Biochemical Metabolism of Glucocorticoid-Induced Necrosis of Femoral Head Treated by Different Approaches

Objective:To compare the effect of three different approaches to prevent and treat glucorticoidinduced necrosis of femoral head. Methods:The animal models made with glucocorticoid were respectively treated with herbal drugs of activating blood and removing stasis,dissipating dampness and the expelling phlegm,reinforcing kidney and strengthening bone,or with water.All animals were killed after 6 weeks treatment in order to collect experimental samples and measure some biochemical parameters. Results:The herbal drugs have the effectiveness of preventing the lose of bone calcium and the decrease of the synthesis of bone matrix,and increasing the concentration of blood calcium and the value of CaPi. We found the approach of activating blood and removing stasis is obviously superior to another two approaches.Conclusion:The herbal drugs of activating blood and removing stasis can improve biochemical metabolism,rectify the negative balance of bone calcium and increase the synthesis of bone matrix and the value of CaPi.