Assignment of the polymorphic intestinal mucin gene (MUC2) to chromosome 11p15 |
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| Authors: | B. GRIFFITHS D. J. MATTHEWS L. WEST J. ATTWOOD S. POVEY D. M. SWALLOW J. R. GUM Y. S. KIM |
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| Affiliation: | MRC Human Biochemical Genetics Unit, University College London, Wolf son House, 4 Stephenson Way, London NW1 2HE;Gastrointestinal Research Laboratory (151M2), Veterans Administration Medical Center, San Francisco, California 94121, USA |
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| Abstract: | A cDNA coding for a mucin expressed in intestine has recently been cloned (Gum et al. 1989). We describe here the use of this cDNA to map the gene (MUC2) to human chromosome 11 using somatic cell hybrids, and to make the regional localization to 11p15 by in situ hybridization. Analysis of the CEPH (Centre 'Étude du Polymorphisme Humain) families revealed that MUC2 forms part of the tight linkage group on llpl5 which contains HRAS, INS, TH and HBBC. |
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