Centromere spreading and out-of-phase chromatid separation in Burkitt's lymphoma and nasopharyngeal carcinoma |
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| Authors: | S H Zhang |
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| Institution: | 1. Wellcome Sanger Institute, Hinxton CB10 1SA, UK;2. Health Innovation East, Unit C, Magog Court, Shelford Bottom, Cambridge CB22 3AD, UK;3. Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain;4. Broad Institute of MIT and Harvard, Cambridge, MA, USA;5. GSK, Gunnels Wood Road, Stevenage SG1 2NY, UK;1. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain;2. Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain;3. School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK;4. School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, NSW 2052, Australia;5. CNAG-CRG, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Baldiri Reixac 4, 08028 Barcelona, Spain;6. Servei de Cultius Cel.lulars-SCAC, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain;7. Institute for Applied Ecology, University of Canberra, Bruce, ACT 2617, Australia;8. School of Biosciences, The University of Melbourne, Victoria, VIC 3010, Australia;9. Evolutionary Genomics Group, Department of Botany and Zoology, Faculty of Science, Stellenbosch University, Private Bag X1, Stellenbosch 7602, South Africa;10. Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, Carrer del Doctor Aiguader 88, 08003 Barcelona, Spain;11. ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain;12. Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain;1. Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA;1. Department of Biology II, Ludwig Maximilians University Munich, Grosshadernerstrasse 2, Planegg-Martinsried 82152, Germany;2. Department of Medical Biology, Medical University-Plovdiv, Boulevard Vasil Aprilov 15A, Plovdiv 4000, Bulgaria;1. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA;2. Division of Human Genetics, Duke University Medical Center, Durham, NC 27710, USA |
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| Abstract: | Chromosomes with various degrees of centromere spreading and completely separated chromatids, as well as metaphasic chromosomes, were observed simultaneously in the same Burkitt's lymphoma cell. In another study, a pair of prematurely and completely separated chromatids was found in a metaphase of nasopharyngeal carcinoma cell. Based on these and other observations, the possible significance of centromere spreading and out-of-phase sister chromatid separation in the origin of chromosome nondisjunction in tumor cells is suggested and discussed. |
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