| 药品不良反应数据库信号检测及其发现 |
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| 引用本文： | 李明,王越,孙骏,张鸣雨,徐厚明,陆叶,张苏琳.药品不良反应数据库信号检测及其发现[J].中国药物警戒,2008,5(2):83-86. |
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| 作者姓名： | 李明 王越 孙骏 张鸣雨 徐厚明 陆叶 张苏琳 |
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| 作者单位： | 1. 江苏省药品不良反应监测中心,江苏,南京,210002
2. 南京医科大学,江苏,南京,210029 |
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| 摘 要： | 目的对2005年江苏省药品不良反应自愿报告数据库进行信号检测。方法采用成比例报告比值法,以PRR-1.96SE〉1;至少有3例以上的报告作为判断标准,并借助计算机信息系统,对2005年江苏省自愿呈报数据库进行定量分析。结果共有937个药品-不良反应组合结果符合信号检测标准,在信号强度排列前100位的组合中有20种未在说明书中出现。结论通过对药品不良反应数据库的定量信号检测,提示新的药品不良反应信号,为进一步的研究提供依据。
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| 关 键 词： | 药品不良反应 信号检测 自愿报告系统 |
| 文章编号： | 1672-8629(2008)02-0083-03 |
| 修稿时间： | 2007年12月25 |
Signal Detection for Adverse Drug Reaction Database |
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| LI Ming,WANG Yue,SUN Jun,ZHANG Ming-yu,XU Hou-ming,LU Ye,ZHANG Su-lin.Signal Detection for Adverse Drug Reaction Database[J].Chinese JOurnal of Pharmacovigilance,2008,5(2):83-86. |
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| Authors: | LI Ming WANG Yue SUN Jun ZHANG Ming-yu XU Hou-ming LU Ye ZHANG Su-lin |
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| Institution: | LI Ming,WANG Yue,SUN Jun,ZHANG Ming-yu,XU Hou-ming,LU Ye,ZHANG Su-lin (1 Jiangsu Center For ADR Monitoring,Jiangsu Nanjing 210002,China; 2 Nanjing Medical University,Jiangsu Nanjing 210029,China) |
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| Abstract: | Objective The Signal for Adverse Drug Reaction(ADR)spontaneous reporting database of Jiangsu Province in 2005 is detected. Methods The database of Jiangsu Center for ADR Monitoring was inves-tigated with the proportional reporting ratios. The signal criterion is PRR-1.96SE>1 and there were at least 3 related reports about them. Results 937 Drug-ADR combinations accord with the signal detection criterion.There are 20 Drug-ADR combinations not indicated in the instruction in the first 100 of signal intensity arrangement. Conclusion New ADR signals were detected in our database, which provide data for further study. |
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| Keywords: | adverse drug reaction signal detection spontaneous reporting system |
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