慢性迁延性乙型肝炎活检肝组织的电子显微镜观察

本文报告9例慢性迁延性乙型肝炎的13份肝穿标本的电镜观察结果。慢迁肝的主要超微结构变化为:(1)滑面内质网增生和扩张是最常见和最明显的改变;(2)粗面内质网数目减少;(3)大多数病例胞浆内核蛋白体和糖元颗粒减少;(4)线粒体呈程度不等的变性。本文对上述所见的机能意义,光镜所见与电镜所见的比较以及病理所见与临床表现的关系进行了讨论。

Electron Microscopic Observations on Liver Biopsied Tissues of Chronic Persistent Hepatitis(CPH)

13 Liver biopsied specimens, taking from 9 cases with CPH were studied by electron microscopy. The diagnosis of CPH in all the patients had been established according to clinical and histological criteria. The main ultrastructural features were as follows: (1)hyperplasia and dilatation of smooth endoplasmic reticulum(sER) is the most common and prominent findings in all the patients, (2)the rough endoplasmic reticulum(rER) is decreased in number, (3)depletion of ribosomes and glycogen granules in cytoplasma were found in most of specimens, and (4)Degenerative changes of Mitochondria were demonstrated in various degree. The functional significances of these findings, comparison with those in light microscopic features, and relationship between pathologic findings and clinical manifestations were discussed.