Protective effect of low-doses of antibodies to S-100 protein on the formation of long-term sensitization in <Emphasis Type="Italic">Helix lucorum</Emphasis> |
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| Authors: | O I Epstein M B Stark A Kh Timoshenko T Kh Gainutdinova Kh L Gainutdinov |
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| Institution: | (1) Materia Medica Company, Russia;(2) Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk;(3) Kazan Physical Technological Institute, Russian Academy of Sciences, Russia |
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| Abstract: | Injection of antibodies to Ca-binding protein S-100 in a dilution of 10−12 before the formation of long-term sensitization in Helix lucorum (10 min before the first electric shock) prevented the increase in defense reactions of pneumostome closure and ommatophore
withdrawal. Thus, we demonstrated a protective effect of low-dose antibodies to S-100 on the formation of long-term sensitization
as a neurobiological model of anxiety and depression.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 5, pp. 490–493, May, 2007 |
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| Keywords: | Ca-binding protein S-10 antibodies to S-100 long-term sensitization neurobiological model of anxiety xxx depression |
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