| Investigation of 4-hydroxynonenal-delved Epitopes on Apolipoprotein B in Human Serum |
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| 作者姓名： | 陈琪 陈丙莺 陈秀英 王南 |
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| 作者单位： | Chen Qi Chen Bingying *\ Chen Xiuying \ Wang Nan Atherosclerosis Research Center，*Department of Biochemistry，Nanjing Medical University，Nanjing 210029，P.R.China |
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| 摘 要： | Ｉｎｖｅｓｔｉｇａｔｉｏｎｏｆ４┐ｈｙｄｒｏｘｙｎｏｎｅｎａｌ┐ｄｅｌｖｅｄＥｐｉｔｏｐｅｓｏｎＡｐｏｌｉｐｏｐｒｏｔｅｉｎＢｉｎＨｕｍａｎＳｅｒｕｍ①ＣｈｅｎＱｉ（陈琪）ＣｈｅｎＢｉｎｇｙｉｎｇ（陈丙莺）＊ＣｈｅｎＸｉｕｙｉｎｇ（陈秀英）ＷａｎｇＮ...
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Investigation of 4 hydroxynonenal delved Epitopes on Apolipoprotein B in Human Serum |
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| Chen Qi Chen Bingying \ Chen Xiuying \ Wang Nan,Atherosclerosis Research Center.Investigation of 4-hydroxynonenal-delved Epitopes on Apolipoprotein B in Human Serum[J].Journal of Nanjing Medical University,1997(1). |
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| Authors: | Chen Qi Chen Bingying \ Chen Xiuying \ Wang Nan Atherosclerosis Research Center |
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| Institution: | Chen Qi Chen Bingying *\ Chen Xiuying \ Wang Nan Atherosclerosis Research Center,*Department of Biochemistry,Nanjing Medical University,Nanjing 210029,P.R.China |
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| Abstract: | hydroxynonenal(HNE) is one of the important products generated in lipid peroxidation. An enzyme linked immunoassay for HNE derived epitopes on apolipoprotein B(apo B) was established and 263 human sera were measured. The mean expression of HNE epitopes in men(156.5 mg/L, n=157) was higher than that in women(147.6 mg/L, n=106). In the subjects less than 70 years of age the serum levels of HNE epitopes increased with the age. Expression of HNE epitopes on apo B in serum positively related to serum contents of ferritin, total cholesterol, triglycerides, and low density lipoprotein cholesterol(LDL C). In addition, mean level of HNE epitopes on apo B in patients with coronary heart disease (CHD, 183.5 mg/L, n=103) was higher than that of controls(133.3 mg/L, n=160). This difference was statistically significant. A multiple regression analysis furth showed that serum concentration of LDL C and HNE epitopes were positively related to CHD as well as the age, but high density lipoprotein cholesterol and female were negatively related to CHD. Thus, increased expression of HNE epitopes on apo B might be an independent risk factor of CHD. \ \ |
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| Keywords: | hydroxynonenal epitopes enzyme linked immunoassay coronary heart disease |
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