Microsphaerones A and B,two novel gamma-pyrone derivatives from the sponge-derived fungus Microsphaeropsis sp |
| |
Authors: | Wang Chang-Yun Wang Bin-Gui Brauers Gernot Guan Hua-Shi Proksch Peter Ebel Rainer |
| |
Affiliation: | Institut für Pharmazeutische Biologie, Heinrich-Heine-Universit?t Düsseldorf, Universit?tsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany. |
| |
Abstract: | Two new metabolites, microsphaerones A (1) and B (2), were identified from the EtOAc extract of the culture of an undescribed fungus of the genus Microsphaeropsis, isolated from the Mediterranean sponge Aplysina aerophoba. Compounds 1 and 2 represent the first examples of gamma-pyrone derivatives of the fungal genus Microsphaeropsis. The structures of the compounds were elucidated on the basis of comprehensive spectral analysis ((1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC NMR, as well as low- and high-resolution ESI and EIMS experiments). The (S)-2-methylsuccinic acid moiety present in 1 was established by GC-MS analysis of a hydrolysis product. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|