| 过氧化物酶体增殖因子活化受体γ激动剂用于治疗皮肤病 |
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| 引用本文： | 林熙然,黄畋. 过氧化物酶体增殖因子活化受体γ激动剂用于治疗皮肤病[J]. 国际皮肤性病学杂志, 2008, 34(6) |
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| 作者姓名： | 林熙然 黄畋 |
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| 作者单位： | 1. 大连医科大学附属第一医院,116011
2. 大连医科大学附属第二医院 |
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| 摘 要： | 新近发现过氧化物酶体增殖因子活化受体γ在皮肤中调节多种重要的功能,包括细胞增殖与分化及免疫和炎症反应,因而可能成为治疗多种皮肤病的新靶标.临床上过氧化物酶体增殖因子活化受体γ激动剂已被试用于银屑病、银屑病性关节炎、特应性皮炎、黑素瘤、多毛症、血管肿瘤和脂肪营养不良等.过氧化物酶体增殖因子活化受体激动剂的研究可能提供皮肤病治疗的新手段.
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| 关 键 词： | 过氧化物酶体增殖物激活受体 皮肤疾病 治疗 |
Peroxisome proliferator-activated receptor-gamma agonists in the treatment of dermatoses |
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| LIN Xi-ran,HUANG Tian. Peroxisome proliferator-activated receptor-gamma agonists in the treatment of dermatoses[J]. International Journal of Dermatology and Venereology, 2008, 34(6) |
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| Authors: | LIN Xi-ran HUANG Tian |
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| Abstract: | Recent data have shown that peroxisome proliferator-activated receptor (PPAR)-gamma regulates many biological processes in skin, including cell proliferation and differentiation, immune response and inflammatory reactions. Thus, it may serve as a novel target for the treatment of various skin disorders. Clinically, PPARgamma agonists have been used to treat psoriasis, psoriatic arthritis, atopic dermatitis, melanoma, hirsutism, vascular tumors and lipodystrophy. Investigations into PPAR agonists may develop new approaches to the treatment of skin disorders. |
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| Keywords: | Peroxisome proliferator-activated receptors Skin diseases Therapy |
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