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| 实验性肺纤维化肺灌洗液磷脂组分分析 | |
| 引用本文： | 刘宏,赵鸣武,耿秋明,廖松林,王玉柱,王焕发.实验性肺纤维化肺灌洗液磷脂组分分析[J].大同医学专科学校学报,2001,21(1):1-5. |
| 作者姓名： | 刘宏 赵鸣武 耿秋明 廖松林 王玉柱 王焕发 |
| 作者单位： | 1. 大同医专内科,037008 2. 北京大学第三医院 3. 北京大学医学部病理学系 |
| 摘 要： | 对博莱霉素肺纤维化大鼠模型不同时期作支气管肺泡灌洗液(BALF)细胞计数与分类、蛋白含量测定和磷脂及其组分测定，并与肺病理变化作对照分析。结果发现BALF细胞计数和分类与肺组织细胞浸润基本一致，BALF蛋白含量增加，磷脂酰甘油(PG)随病变进展而下降，磷脂酰肌醇(PI)和磷脂酰乙醇胺(PE)升高。PG／PI比值下降，PG／PI比值可作为肺纤维化的一种标志。 |
| 关 键 词： | 实验 肺纤维化 肺灌洗液 磷脂组分 大鼠 细胞计数 含量测定 |
| 修稿时间： | 2001年1月18日 |
Phospholipid comoonents in BALFS from Bleomycin induced pulmonary fibrosis in rats |
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| Liu Hong,Zhao Ming-Wu,Geng Qiu -ming.et al..Phospholipid comoonents in BALFS from Bleomycin induced pulmonary fibrosis in rats[J].Journal of Datong Medical College,2001,21(1):1-5. | |
| Authors: | Liu Hong Zhao Ming-Wu Geng Qiu -ming |
| Abstract: | Qualitative and quantitative analysis was performed on 5 components of phospholipids(PL) isolated from bronchoalveolar lavage fluid (BALF) during the development of Blepmycin induced pulmonary fibrosis in rats with high - performance liquid chromatography (HPLC). The measurement of cells and protein in BALF,the pathologic and morphometric observation with light and electronic microscope were also done. Results indicated that the changes both in BALF cells and in lung histoapthology were similar,the amount of protein in BALF increased, the total amount of PL in BALF increased more than 1. 8 - fold over control animals at days 28 afrer administration of Bleomycin, phosphatidylglycerol (PG) decreased, the PG/PI ratio could be used as a marker for pulmonary fibrosis. |
| Keywords: | Pulmonary fibrosis Phospholipids Bronchoalveolar lavage fluid Bleomycin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |