| 不同交联度的医用级壳聚糖的降解研究 |
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| 引用本文： | 高萍,鲍世兰,刘欣,史弘道.不同交联度的医用级壳聚糖的降解研究[J].生物医学工程与临床,2002,6(4):188-190. |
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| 作者姓名： | 高萍 鲍世兰 刘欣 史弘道 |
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| 作者单位： | 天津市医药科学研究所,天津,300070 |
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| 摘 要： | 目的：研究不同交联度的医用级壳聚糖在体内、体外的降解性。方法：通过体外酶解试验和动物体内植入试验研究不同交联度的医用级壳聚糖的降解性能。结果：壳聚糖的降解速度随着交联度的增大而减慢。结论：壳聚糖是一种可生物降解材料，其交联度的大小直接影响其降解速度。
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| 关 键 词： | 生物降解 戊二醛 溶菌酶 交联度 医用级壳聚糖 降解研究 |
| 文章编号： | 1009-7090(2002)04-0188-03 |
| 修稿时间： | 2002年3月11日 |
The Study of the Degradation for Medical Chitosan in Different Degree of Crosslinking |
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| GAO Ping,BAO Shi-lan,LIU Xin,SHI Hong-dao Tianjin Medical Biomaterial Inspection & Research Center,Tianjin Institute of Medical & Pharmaceutical Science,Tianjin ,China.The Study of the Degradation for Medical Chitosan in Different Degree of Crosslinking[J].Biomedical Engineering and Clinical Medicine,2002,6(4):188-190. |
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| Authors: | GAO Ping BAO Shi-lan LIU Xin SHI Hong-dao Tianjin Medical Biomaterial Inspection & Research Center Tianjin Institute of Medical & Pharmaceutical Science Tianjin China |
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| Institution: | GAO Ping,BAO Shi-lan,LIU Xin,SHI Hong-dao Tianjin Medical Biomaterial Inspection & Research Center,Tianjin Institute of Medical & Pharmaceutical Science,Tianjin 300070,China |
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| Abstract: | Objective To study in vivo and vitro the degradability of medical chitosan in different degree of crosslinking. Methods The degradation of medical chitosan in different degrees of crosslinking were studied by enzymolysis in vitro and animal implantation in vivo. Results It was showed when the crosslinking degree of chitosan was increasing,the speed of degradation was lowering. Conclusion It is demonstrated that chitosan is a biodegradable material and its degradability is depending on the crosslinking degree of the material. |
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| Keywords: | chitosan biodegradability glutaraldehyde lysozyme |
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