Liposomal encapsulated anti-cancer drugs |
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| Authors: | Hofheinz Ralf-Dieter Gnad-Vogt Senta Ulrike Beyer Ulrich Hochhaus Andreas |
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| Institution: | Onkologisches Zentrum, III. Medizinische Klinik, Fakult?t für Klinische Medizin Mannheim, Universit?t Heidelberg, Mannheim, Germany. ralf.hofheinz@med3.uni-heidelberg.de |
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| Abstract: | Among several drug delivery systems, liposomal encapsulated anti-cancer agents represent an advanced and versatile technology. Several formulations of liposomal anthracyclines are approved, e.g. for the treatment of metastatic breast cancer (pegylated and non-pegylated liposomal doxorubicin) or AIDS-related Kaposi's sarcoma (pegylated liposomal doxorubicin and liposomal daunorubicin). Meanwhile, virtually all anti-cancer drugs have been encapsulated in liposomes using different technologies. This review will summarize preclinical and clinical data of approved and exemplary emerging liposomal anti-cancer agents. |
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