| Abstract: | In this paper, micro-in-macro gelatin-encap-sulated activated charocal (MMAC), a doublegelatin-coated activated charcoal, is recommend-ed a.s an effective adsorbent for clinical hemo-perfusion (HP). In vitro studies show that theclearance and adsorption values for a variety ofsubstances are as good as those with uncoated orcollodion- coated activated cocon ut charcoal.Blood compatibility is excellent and particulaterelease minimal. Clinical conditions for whichMMAC HP has been tried include acute drugoverrdose, po.isoning, chronic uremia and schizo-phrenia. Experience suggesits that MMAC HP iseffective and safe in the treatment of intoxica-tifflis. It is also a useful adjunct to hemodialysisin the treatment of uremia. As for schizophrenia,further study is needed. The shortcomings ofMMAC are also discussed. |
